产品描述
Syrosingopine has selective depleting effect on brain amines is potentiated by combined treatment with disulfiram or fusaric acid, a dopamine beta-hydroxylase inhibitor.
体外活性
The anticancer activity of the widely used diabetic drug metformin is strongly potentiated by Syrosingopine. Synthetic lethality elicited by combining the two drugs is synergistic and specific to transformed cells. This effect is unrelated to Syrosingopine??s known role as an inhibitor of the vesicular monoamine transporters. Syrosingopine binds to the glycolytic enzyme α±-enolase in vitro, and the expression of the γ-enolase isoform correlates with nonresponsiveness to the drug combination. Syrosingopine sensitized cancer cells to metformin and its more potent derivative phenformin far below the individual toxic threshold of each compound[1]
参考文献
[1]Syrosingopine sensitizes cancer cells to killing by metforminSci. Adv.,2016 Dec; 2(12): e1601756.
引用文献
[1]Tian L R, Lin M Z, Zhong H H, et al. Nanodrug regulates lactic acid metabolism to reprogram the immunosuppressive tumor microenvironment for enhanced cancer immunotherapy. Biomaterials Science. 2022
储存和溶解度
DMSO:62.5 mg/mL (93.74 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years