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TargetMol.T1418.Bucladesine sodium布拉地新钠盐
  • 品牌:TargetMol
  • 型号:25 mg
  • 货号:T1418
  • cas:16980-89-5
  • 价格: ¥300/瓶
  • 发布日期: 2023-05-08
  • 更新日期: 2024-08-30
产品详请
产地
品牌 TargetMol
货号 T1418
用途
英文名称
包装规格 25 mg
纯度 %
CAS编号 16980-89-5
别名 布拉地新钠盐
分子式
是否进口
产品描述
Bucladesine, PKA activator, is a cyclic nucleotide derivative that mimics the action of endogenous cAMP and is capable of permeating the cell membrane. It has vasodilator properties and is used as a cardiac stimulant.
体外活性
In cultured rat hepatocytes, Bucladesine has the affection of inhibited of NF-κB-binding activity and inducible nitric oxide synthase expression. Bucladesine also inhibits TNFα-induced hepatocyte apoptosis by suppressing FADD up-regulation.
体内活性
In a mouse model, bucladesine (600 nM, i.p.) reverses lead acetate- and zinc chloride-induced impairments of avoidance memory retention.
动物实验
Animal: Mice. Formulation: water/DMSO (9:1). Dosages: 600 nM. Administration: i.p.
Cas No.
16980-89-5
分子式
C18H23N5NaO8P
分子量
491.373
别名
Dibutyryl-cAMP;Dibutyryl-cAMP sodium salt;DC2797;Bucladesine;dbcAMP;Bucladesine sodium salt;布拉地新钠盐;Sodium dibutyryl cAMP;Bucladesine sodium
参考文献
[1]Prapong T, et al. Exp Neurol. 2001, 167(1), 59-64. [2]Xu C, Zhao W, Huang X, et al. TORC2/3-mediated DUSP1 upregulation is essential for human decidualization[J]. Reproduction. 2021, 1(aop). [3]Biol Trace Elem Res. 2015, DOI10.1007/s12011-015-0399-z [4]Harbrecht BG, et al. J Surg Res. 2001, 99(2), 258-264. [5]Wang Y, et al. Apoptosis. 2006, 11(3), 441-451.
引用文献
[1]Xu C, Zhao W, Huang X, et al. TORC2/3-mediated DUSP1 upregulation is essential for human decidualization. Reproduction. 2021, 1(aop).
储存和溶解度
H2O:49.1 mg/mL (100 mM)
DMSO:49.1 mg/mL (100 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years