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TargetMol.T4081.MPTP hydrochloride
  • 品牌:TargetMol
  • 型号:5 mg
  • 货号:T4081
  • cas:23007-85-4
  • 价格: ¥335/瓶
  • 发布日期: 2023-05-08
  • 更新日期: 2024-08-30
产品详请
产地
品牌 TargetMol
货号 T4081
用途
英文名称
包装规格 5 mg
纯度 %
CAS编号 23007-85-4
别名
分子式
是否进口
产品描述
MPTP-hydrochloride is a precusor of MPP+ which is toxic to dopaminergic neurons and causes Parkinsonism.
体外活性
Pretreatment with 50 mM 4-phenylpyridine, reduces IC50 (concentration for 50% inhibition of twitch amplitude) values of MPTP from 53 to 18 mM and d-tubocurarine from 0.7 to 0.3 mM, respectively, in mouse phrenic nerve-diaphragm[3].
体内活性
The toxic effect of MPTP can be completely abolished in vivo by treatment with a monoamine oxidase inhibitor and potentiated by an inhibitor of catechol-O-methyltransferase[1]. Allopurinol potentiated the MPTP (35 mg/kg)-induced decrease in the DOPAC+HVA/DA ratio and increase in striatal AA oxidation of the rat[2]. Gas1 expressions are significantly elevated in the majority of the reactive astrocytes of the brains with LPS or MPTP insults in animal models[4].
Cas No.
23007-85-4
分子式
C12H16ClN
分子量
209.72
别名
MPTP-hydrochloride;MPTP hydrochloride
参考文献
[1]Desole M S, et al. Further investigation of allopurinol effects on MPTP-induced oxidative stress in the striatum and brain stem of the rat. Source:Pharmacol.Biochem.Behav., 1996, 54, No. 2, 377-83. [2]Langston J W, Irwin I. MPTP Neurotoxicity: An Overview and Characterization of Phases of Toxicity. II. Selective Accumulation of MPP in the Substantia Nigra: A Key to Neurotoxicity (Question). Life Sci., 1985, 36, No. 3, 201-12. [3]Sun XL, et al. Gas1 up-regulation is inducible and contributes to cell apoptosis in reactive astrocytes in the substantia nigra of LPS and MPTP models. J Neuroinflammation. 2016 Jul 8;13(1):180. [4]Hsu K S, et al. Potentiation of MPTP by 4-Phenylpyridine on the Neuromuscular Blockade in Mouse Phrenic Nerve-Diaphragm. Neuropharmacology, 1993, 32, No. 9, 877-83.
储存和溶解度
DMSO:12 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years