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15195831611
服务热线
15195831611
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| 产地 | |
| 保存条件 | 2-8℃ |
| 品牌 | Sigma-Aldrich |
| 货号 | ABD136 |
| 用途 | |
| 组织来源 | |
| 细胞形态 | |
| 是否是肿瘤细胞 | |
| 保质期 | |
| 器官来源 | |
| 免疫类型 | |
| 品系 | |
| 生长状态 | |
| 物种来源 | |
| 包装规格 | 100 μg |
| 是否进口 | 是 |
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| M | WB | Rb | Affinity Purified | Polyclonal Antibody |
| Description | |
|---|---|
| Catalogue Number | ABD136 |
| Description | Anti-LGI1 Antibody |
| Alternate Names |
|
| Background Information | Leucine-rich glioma inactivated gene 1 (LGI1), also known as Epitempin-1 (EPT), is a member of a family of highly related proteins containing leucine-rich repeats (LRRs) regulating voltage-gated potassium channels assembled from KCNA1, KCNA4 and KCNAB1. LGI1 may play a role in the control of neuroblastoma cell survival and may play a role in other cancers. It is expressed in neural tissue, especially brain. Mutations in LGI1 have been associated with nearly half of autodominant lateral temporal epilepsy (ADTLE). |
| Product Information | |
|---|---|
| Format | Affinity Purified |
| Control |
|
| Presentation | Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide. |
| Quality Level | MQ100 |
| Applications | |
|---|---|
| Application | Detect LGI1 using this rabbit polyclonal antibody, Anti-LGI1 Antibody validated for use in western blotting. |
| Key Applications |
|
| Biological Information | |
|---|---|
| Immunogen | KLH-conjugated linear peptide corresponding to the N-terminus of human LGI1. |
| Epitope | N-terminus |
| Concentration | Please refer to the Certificate of Analysis for the lot-specific concentration. |
| Host | Rabbit |
| Specificity | This antibody recognizes the N-terminus of LGI1. |
| Species Reactivity |
|
| Species Reactivity Note | Demonstrated to react with Mouse. Predicted to react with Human based on immunogen design. |
| Antibody Type | Polyclonal Antibody |
| Gene Symbol |
|
| Purification Method | Antigen Affinity Purified |
| UniProt Number |
|
| Molecular Weight | ~56 kDa observed. Uniprot describes 3 isoforms at ~33 kDa, ~58 kDa, and ~64 kDa. Uncharacterized bands may appear in some lysates. |
| Product Usage Statements | |
|---|---|
| Quality Assurance |
Evaluated by Western Blotting/Peptide Inhibition Assay in mouse brain tissue lysate. Western Blotting/Peptide Inhibition Assay Analysis: 1 μg/mL of this antibody detected LGI1 in 15 μg of mouse brain tissue lysate. |
| Usage Statement |
|
| Storage and Shipping Information | |
|---|---|
| Storage Conditions | Stable for 1 year at 2-8°C from date of receipt. |
| Packaging Information | |
|---|---|
| Material Size | 100 μg |
