Oridonin is a diterpenoid isolated from Rabdosia rubescens with anti-tumor, anti-bacterial and anti-inflammatory effects. It acts as an inhibitor of AKT, with IC50s of 8.4 and 8.9 μM for AKT1 and AKT2.

LD50: Mice 35-40 mg/kg. [4]

28957-04-2

C20H28O6

364.438

冬凌草甲素;Rubescensin A;Isodonol;NSC-250682;Rubescenin;Oridonin

[1]Ikezoe T, et al. Int J Oncol, 2003, 23(4), 1187-1193. [2]Ikezoe T, et al. Mol Cancer Ther, 2005, 4(4), 578-586. [3]Cui Q, et al. J Pharmacol Sci, 2007, 105(4), 317-325.

[1]Li L, Song J, Zhang M, et al. Oridonin ameliorates caspase-9-mediated brain neuronal apoptosis in mouse with ischemic stroke by inhibiting RIPK3-mediated mitophagy. Acta Pharmacologica Sinica. 2022: 1-15. [2]An Y, Zhu J, Wang X, et al. Oridonin Delays Aging Through the AKT Signaling Pathway. Frontiers in Pharmacology. 2022: 1823 [3]Li L, Cheng S Q, Guo W, et al. Oridonin prevents oxidative stress‐induced endothelial injury via promoting Nrf‐2 pathway in ischaemic stroke. Journal of Cellular and Molecular Medicine. 2021

Ethanol:28 mg/mL (76.83 mM)
H2O:<1 mg/mL
DMSO:72 mg/mL (197.57 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years