Liproxstatin-1 is a potent ferroptosis inhibitor.

Liproxstatin-1与溶剂对照组相比,可明显地延长生存期,抑制小管上皮细胞中铁死亡,并减轻了局部缺血/再灌注引起的肝损伤中的组织损伤.

Liproxstatin-1（200 nM）以剂量依赖的方式保护免受FINs（例如BSO（10 μM）,erastin（1 μM）和RSL3（0.5 μM））诱发的细胞死亡,而不能阻断由0.2 μM 十字孢碱和200 μM H2O2诱发的细胞死亡。Liproxstatin-1能够在低纳摩尔范围内抑制铁死亡,并抑制Gpx4 -/- 细胞的生长,IC50为22 nM。Liproxstatin-1（50 nM）完全防止Gpx4 -/- 细胞的脂质过氧化。

Cell viability is assessed at different time points after treatment using AquaBluer according to the manufacturer’s recommendations. Alternatively, cell death is also quantified by measuring released lactate dehydrogenase activity using the cytotoxicity detection kit (LDH). (Only for Reference)

950455-15-9

C19H21ClN4

340.85

Liproxstatin-1

[1]Su G, Yang W, Wang S, et al. SIRT1-autophagy axis inhibits excess iron-induced ferroptosis of foam cells and subsequently increases IL-1Β and IL-18[J]. Biochemical and Biophysical Research Communications. 2021, 561: 33-39. [2]Friedmann Angeli JP, et al. Nat Cell Biol. 2014, 16(12):1180-1191. [3]Rui T, Wang H, Li Q, et al. Deletion of ferritin H in neurons counteracts the protective effect of melatonin against traumatic brain injury‐induced ferroptosis[J]. Journal of Pineal Research. 2020: e12704.

[1]Wu M, Zhang X, Zhang W, et al. Cancer Stem Cell Regulated Phenotypic Plasticity Protects Metastasized Cancer Cells from Ferroptosis. Nature Communications. 2022, 13(1): 1-16. [2]Ning X, Qi H, Yuan Y, et al. Identification of a new small molecule that initiates ferroptosis in cancer cells by inhibiting the system Xc? to deplete GSH. European Journal of Pharmacology. 2022: 175304. [3]Cheng Y, Qu W, Li J, et al. Ferristatin II, an Iron Uptake Inhibitor, Exerts Neuroprotection against Traumatic Brain Injury via Suppressing Ferroptosis. ACS Chemical Neuroscience. 2022 [4]Su G, Yang W, Wang S, et al. SIRT1-autophagy axis inhibits excess iron-induced ferroptosis of foam cells and subsequently increases IL-1Β and IL-18. Biochemical and Biophysical Research Communications. 2021, 561: 33-39. [5]Rui T, Wang H, Li Q, et al. Deletion of ferritin H in neurons counteracts the protective effect of melatonin against traumatic brain injury‐induced ferroptosis. Journal of Pineal Research. 2020: e12704. [6]Ouyang S, Li H, Lou L, et al. Inhibition of STAT3-ferroptosis negative regulatory axis suppresses tumor growth and alleviates chemoresistance in gastric cancer. Redox Biology. 2022: 102317 [7]Yu F, Zhang Q, Liu H, et al. Dynamic O-GlcNAcylation coordinates ferritinophagy and mitophagy to activate ferroptosis. Cell Discovery. 2022, 8(1): 1-17 [8]Luo Y, Gao X, Zou L, et al. Bavachin Induces Ferroptosis through the STAT3/P53/SLC7A11 Axis in Osteosarcoma Cells. Oxidative Medicine and Cellular Longevity. 2021 [9]Zhou Y, Wu H, Wang F, et al. GPX7 Is Targeted by miR-29b and GPX7 Knockdown Enhances Ferroptosis Induced by Erastin in Glioma. Frontiers in oncology. 2021, 11: 802124-802124. [10]Huang C Y, Chen L J, Chen G, et al. SHP-1/STAT3-Signaling-Axis-Regulated Coupling between BECN1 and SLC7A11 Contributes to Sorafenib-Induced Ferroptosis in Hepatocellular Carcinoma. International Journal of Molecular Sciences. 2022, 23(19): 11092.

Ethanol:soluble
H2O:Insoluble
DMSO:60 mg/ml (176.03 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years