G-418 (disulfate) is an aminoglycoside antibiotic, which blocks polypeptide synthesis by inhibiting the elongation step in both prokaryotic and eukaryotic cells.

40到80 mg/kg剂量的G418连续处理三天足以消除感染小鼠的所有未转染布氏黄杆菌寄生虫.

G418浓度为1-300 microgram/ml时,抑制多种原核和真核生物。一般作用于细菌和藻类的浓度为5 mg/L或更低浓度,用于筛选哺乳动物细胞浓度为400 mg/L,维持哺乳动物细胞的浓度为200 mg/L。

108321-42-2

C20H44N4O18S2

692.7

Geneticin;G418 Sulfate;Geneticin sulfate;Antibiotic G-418 sulfate;遗传霉素;G-418 disulfate

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DMSO:Insoluble
H2O:43.31mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years