Puromycin hydrochloride is a cinnamamido ADENOSINE found in STREPTOMYCES alboniger. It inhibits protein synthesis by binding to RNA. It is an antineoplastic and antitrypanosomal agent and is used in research as an inhibitor of protein synthesis.

Puromycin能够用于从非培养细胞中选择重组细胞。在许多体系中Puromycin被用作研究蛋白质合成的工具。

58-58-2

C22H31Cl2N7O5

544.43

Puromycin 2HCl;CL13900 dihydrochloride;嘌呤霉素二盐酸盐水合物;嘌呤霉素二盐酸盐;Puromycin dihydrochloride

[1]Watanabe S, et al. Biol Reprod. 2005, 72(2), 309-315. [2]Han W, Zhang C, Shi C, et al. Roles of eIF3m in the tumorigenesis of triple negative breast cancer[J]. Cancer Cell International. 2020, 20(1): 1-16. [3]Gao C, Wang H, Wang T, et al. Platelet CLEC‐2 regulates neuroinflammation and restores blood brain barrier integrity in a mouse model of traumatic brain injury[J]. Journal of Neurochemistry. 2020: e14983. [4]Han W, Cao F, Gao X J, et al. ZIC1 acts a tumor suppressor in breast cancer by targeting survivin[J]. International journal of oncology . 2018 Sep;53(3):937-948. [5]Darken MA. Pharmacol Rev. 1964, 16, 223-243.

[1]Wang Y N, Ruan D Y, Wang Z X, et al. Targeting the cholesterol-RORα/γ axis inhibits colorectal cancer progression through degrading c-myc. Oncogene. 2022: 1-13. [2]Gao C, Wang H, Wang T, et al. Platelet CLEC‐2 regulates neuroinflammation and restores blood brain barrier integrity in a mouse model of traumatic brain injury. Journal of Neurochemistry. 2020: e14983 [3]Han W, Zhang C, Shi C, et al. Roles of eIF3m in the tumorigenesis of triple negative breast cancer. Cancer Cell International. 2020, 20(1): 1-16 [4]Han W, Cao F, Gao X J, et al. ZIC1 acts a tumor suppressor in breast cancer by targeting survivin. International Journal of Oncology. 2018 Sep;53(3):937-948

H2O:92 mg/mL (169 mM)
DMSO:54.4 mg/mL(100 mM)
Ethanol:<1 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years