Wedelolactone inhibits NF-κB-mediated gene transcription in cells by blocking the phosphorylation and degradation of IκBα.

524-12-9

C16H10O7

314.249

蟛蜞菊内酯;IKK Inhibitor II;Wedelolactone

[1]Nehybová T, et al. Wedelolactone Acts as Proteasome Inhibitor in Breast Cancer Cells. Int J Mol Sci. 2017 Mar 29;18(4). [2]ROMANCHIKOVA N, TRAPENCIERIS P. Wedelolactone Targets EZH2-mediated Histone H3K27 Methylation in Mantle Cell Lymphoma[J]. Anticancer research. 2019, 39(8): 4179-4184.

[1]Pan H, Lin Y, Dou J, et al. Wedelolactone facilitates Ser/Thr phosphorylation of NLRP3 dependent on PKA signalling to block inflammasome activation and pyroptosis. Cell Proliferation. 2020, 53(9): e12868 [2]ROMANCHIKOVA N, TRAPENCIERIS P. Wedelolactone Targets EZH2-mediated Histone H3K27 Methylation in Mantle Cell Lymphoma. Anticancer Research. 2019, 39(8): 4179-4184

DMSO:57 mg/mL(181.4 mM)
Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.:Soluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years