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产地 | |
品牌 | ENZO |
货号 | ADI-900-019A |
用途 | |
英文名称 | |
包装规格 | 96 wells |
纯度 | % |
CAS编号 | |
别名 | |
分子式 | |
是否进口 | 是 |
产品信息
产品货号 |
ADI-900-019A |
产品名称 |
Leptin (mouse), ELISA kit(小鼠瘦素ELISA试剂盒) |
规格 |
96 wells |
灵敏度 |
25.4 pg/ml |
检测范围 |
50-3,200 pg/ml |
检测时间 |
3 hours |
样本种属 |
Mouse |
样本类型 |
culture supernatants, plasma, and serum. Cited sample type includes tissue |
保存温度 |
+4°C |
试剂盒组分 |
Microtiter plate, Standard, Antibody, Conjugate, Assay buffer 28, TMB Substrate, Stop solution 2, Wash buffer concentrate |
产品简介:
瘦素(Leptin)是由ob基因编码、在脂肪组织中生成的一种脂肪代谢调控产物,在代谢和调控体重等方面发挥重要作用。它通过下丘脑中的瘦素受体发出信号,降低食欲,增加能量消耗。在外周组织中,瘦素能拮抗胰岛素信号传导,增加脂肪酸氧化,减少胰岛β细胞的胰岛素分泌,并促进生育。它在脂肪细胞中的表达可以被其他脂肪因子如IL-6(刺激)和TNF-α(抑制)以旁分泌方式调节。瘦素缺乏的小鼠表现出严重的胰岛素抵抗、肥胖和生育能力下降,所有这些都可以通过外源性瘦素给药而逆转。还有研究表明,瘦素与心血管疾病有关,因为它介导了许多促炎和促动脉粥样硬化作用,如内皮素-1(ET-1)表达增加、活性氧(ROS)积累、单核细胞趋化蛋白-1(MCP-1)分泌以及交感血管张力和血压增加。
● 灵活:适用于正常和病理样本
● 高灵敏:可检测<26 pg/ml的小鼠瘦素水平
● 快速:仅需3小时就可获得39个样本的重复结果
● 方便:预包被板和即用型试剂为您节省实验时间
引用文献
1. High salt diet does not impact the development of acute myeloid leukemia in mice: M. Janakiraman, et al.; Cancer Immunol. Immunother. 72, 265 (2023)
2. eNAMPT actions through nucleus accumbens NAD+/SIRT1 link increased adiposity with sociability deficits programmed by peripuberty stress: L. Morató, et al.; Sci. Adv. 8, eabj9109 (2022)
3. Transcription factor CREB3 is a potent regulator of high-fat diet-induced obesity and energy metabolism: B.S. Smith, et al.; Int. J. Obes. 46, 1446 (2022)
4. The effects of mirabegron on obesity-induced inflammation and insulin resistance are associated with brown adipose tissue activation but not beiging in the subcutaneous white adipose tissue: C. Peres Valgas da Silva, et al.; Clin. Exp. Pharmacol. Physiol. 48, 1477 (2021)
5. Anti-Obesity Effects of Collagen Peptide Derived from Skate (Raja kenojei) Skin Through Regulation of Lipid Metabolism: M. Woo, et al.; Mar. Drugs 16, 306 (2018)
6. Anti-obesity effects of pectinase and cellulase enzyme?treated Ecklonia cava extract in high?fat diet?fed C57BL/6N mice: I.H. Kim, et al.; Int. J. Mol. Med. 41, 924 (2018), Application(s): ELISA using mouse serum